详细描述：
IRDye® 800CW BoneTag Optical Probe and IRDye 680RD BoneTag Optical Probe are calcium-chelating compounds conjugated to IRDye 800CW or IRDye 680RD near-infrared dye. Use of IRDye NIR dyes extends fluorescence signal detection to the NIR region of the spectrum without affecting the compound’s ability to function as a marker of the mineralization process. NIR fluorescence detection improves depth of penetration due to low tissue autofluorescence, translating to low background interference.The ability to visualize bone anatomy and structures for an extended period facilitates use of the IRDye BoneTag in conjunction with a second optical agent specific for a primary target (i.e, tumor tissue). In addition, IRDye 800CW BoneTag may prove effective for studies dealing with bone metastasis and bone remodeling studies.
