详细描述：
LGC Biosearch提供多种多样的寡核苷酸化学修饰方式，修饰类型从碱基修饰到荧光报告基团和猝灭基团标记，修饰位置包括3'端修饰、5'端修饰以及内部修饰，可任意排列组合，种类丰比任何一家提供Oligo定制或引物合成的公司都要多。
Biosearch Technologies offers more modifications than any other custom oligo supplier. From modified bases to fluorescent reporter and quencher labels, Biosearch offers a complete array of modifications for 3', 5' and internal labeling.
The 5-JOET modification incorporates a fluorescent 6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein (JOE) moiety at the 5' terminus of an oligonucleotide. This 5’ JOE modification is conjugated to a modified thymidine which may participate in hybridization. 5' JOE modified oligonucleotides can be used in a wide array of applications, including dual-labeled fluorogenic probes for real-time PCR. JOE is a xanthene dye and this product is prepared using the 6-carboxy isomer. JOE fluoresces in the yellow region of the visible spectrum and can be effectively quenched by BHQ®-1 dye.
